Pérez Galera, SalvadorBravo Ferrer, Jose M.Paniagua, MaríaKostyanev, TomislavKraker, Marlieke E.A. deFeifel, JanSojo Dorado, JesúsSchotsman, JoostCantón, RafaelDaikos, George L.Carevic, BiljanaSpyridis, NikolaosDorneanu, OliviaMichos, AthanasiosRosa, Francesco Giuseppe deMasanovic, MilevaCavallo, RossanaPetrosillo, NicolaDicaro, AntonioLandini, Maria PaolaMatkovic, DusanLupse, MihaelaTsiodras, SotiriosKapisyzi, PerlatBlasi, FrancescoPasquale, Marta diViscoli, ClaudioVata, AndreiVince, AdrianaKurti, ArsimTsigou, EvdoxiaMaltezos, EfstratiosDragovac, GoranaKomnos, ApostolosGogos, CharalamposFranzetti, FabioAntonelli, MassimoCorneci, DanTomescu, DanaDíaz Pollán, BeatrizGeorgescu, AncaBukarica, LjiljanaMitrović, GoranKrstić, Nataša LukićOrigüen Sabater, JuliaCano Yuste, ÁngelaMuñoz, PatriciaTan, Lionel K.Azap, AlpaySancak, BanuSahin, ArifeAkalin, HalisRaka, LulBonten, Marc J.Hristea, AdrianaViale, PierluigiRoilides, EmmanuelAkova, MuratReguera, Jose MaríaValiente de Santis, LucíaTorre Cisneros, JuliánRadulovic, LiliKirakli, CenkGutiérrez Gutiérrez, BelénShaw, EvelynFalagas, Matthew E.Pintado, VicenteGoossens, HermanRodríguez Baño, JesúsPérez Camacho, InésSerna, Almudena de laMonteau, SophiePalomo, VirginiaSoriano, ElenaGutiérrez, DavidMoreno, ElisaPalacios Baena, Zaira R.Chorafa, ElsaMorales, IsabelMaldonado, NataliaFrutos Adame, AzaharaPlata, AntonioRuiz Mesa, Juan DiegoSobrino Díaz, BeatrizMárquez Gómez, IgnacioGuzmán Puche, JuliaGracia Ahufinger, IreneRadovanovic, IvanaPérez Nadales, ElenaTorre Giménez, JuliánPyrpasopoulou, AthinaIosifidis, EliasPetrovic, SladjanaMargarita, KyriakidouCvetkovi, SlavicaMelentijevic, Srdjan-SanjaBicmen, CanSenol, GunesTubau, FeCámara, JordiGumucio, Victor DanielTalapan, DanielaBassoulis, DimitrisDeliolanis, JohnGijón Cordero, DesiréePitiriga, Vassiliki Ch.Triarides, NikolaosArgiti, EfstathiaLegakis, Nikolaos J.Ruiz Garbajosa, PatriciaBartoloni, AlessandroMedić, DeanaRossolini, Gian MariaFlorescu, Simin-AyselNica, MariaBenea, SerbanPrijić, Sanja MaričićCiofi degli Atti, Marta LuisaCantero Caballero, MireiaParra Ramírez, Lina M.Korten, VolkanBilgin, HüseyinDalekos, George N.Stefos, Aggelos2023-08-012023-08-012023-03-012589-5370https://hdl.handle.net/2445/201442Cases were patients with complicated urinary tract infection (cUTI), complicated intraabdominal (cIAI), pneumonia or bacteraemia from other sources (BSI-OS) due to CRE; control groups were patients with infection caused by carbapenem-susceptible Enterobacterales (CSE), and by non-infected patients, respectively. Matching criteria included type of infection for CSE group, ward and duration of hospital admission. Conditional logistic regression was used to identify risk factors. Findings Overall, 235 CRE case patients, 235 CSE controls and 705 non-infected controls were included. The CRE infections were cUTI (133, 56.7%), pneumonia (44, 18.7%), cIAI and BSI-OS (29, 12.3% each). Carbapenemase genes were found in 228 isolates: OXA-48/like, 112 (47.6%), KPC, 84 (35.7%), and metallo-beta-lactamases, 44 (18.7%); 13 produced two. The risk factors for CRE infection in both type of controls were (adjusted OR for CSE controls; 95% CI; p value) previous colonisation/infection by CRE (6.94; 2.74-15.53; <0.001), urinary catheter (1.78; 1.03-3.07; 0.038) and exposure to broad spectrum antibiotics, as categorical (2.20; 1.25-3.88; 0.006) and time-dependent (1.04 per day; 1.00-1.07; 0.014); chronic renal failure (2.81; 1.40-5.64; 0.004) and admission from home (0.44; 0.23-0.85; 0.014) were significant only for CSE controls. Subgroup analyses provided similar results. Interpretation The main risk factors for CRE infections in hospitals with high incidence included previous coloni-zation, urinary catheter and exposure to broad spectrum antibiotics.12 p.application/pdfengcc by-nc-nd (c) Pérez Galera, Salvador et al, 2023http://creativecommons.org/licenses/by-nc-nd/3.0/es/EnterobacteriàciesInfeccionsEnterobacteriaceaeInfectionsinfo:eu-repo/semantics/article2023-07-31info:eu-repo/semantics/openAccess36895801