Ferrer, Isidro (Ferrer Abizanda)Tuñón, TeresaSerrano Piñol, M. TeresaCasas, RosauraAlcántara Horrillo, SoledadZújar, M. J.Rivera, R. M.2012-05-142012-05-1419930022-3050https://hdl.handle.net/2445/25546The morphology and distribution of local-circuit neurons (interneurons) were examined, by calbindin D-28k and parvalbumin immunocytochemistry, in the frontal cortex (area 8) in two patients with frontal lobe dementia of non-Alzheimer type associated with classical amyotrophic lateral sclerosis (ALS), and in seven normal cases. The density of calbindin D-28k immunoreactive cells was dramatically reduced in ALS patients, but the density of parvalbumin-immunoreactive neurons was preserved. Decreased density of calbindin D-28k-immunoreactive neurons, which are mainly located in the upper cortical layers, may interfere with the normal processing of cortico-cortical connections, whereas integrity of parvalbumin-immunoreactive cells may be associated with the preservation of the major inhibitory intracortical circuits in patients with frontal lobe dementia.5 p.application/pdfeng(c) British Medical Journal, 1993Esclerosi lateral amiotròficaLòbul frontalDemènciaAmyotrophic lateral sclerosisFrontal lobeDementiainfo:eu-repo/semantics/article92192info:eu-repo/semantics/openAccess8459241