Harrison, Ben J.Pujol Nuez, JesúsContreras Rodríguez, OrenSoriano Mas, CarlesLópez-Solà, MarinaDeus Yela, JuanOrtiz, HectorBlanco Hinojo, Laura, 1981-Alonso Ortega, María del PinoHernández Ribas, RosaCardoner, N. (Narcís)Menchón Magriñá, José Manuel2013-06-062013-06-0620111932-6203https://hdl.handle.net/2445/44092Activity decreases, or deactivations, of midline and parietal cortical brain regions are routinely observed in human functional neuroimaging studies that compare periods of task-based cognitive performance with passive states, such as rest. It is now widely held that such task-induced deactivations index a highly organized"default-mode network" (DMN): a large-scale brain system whose discovery has had broad implications in the study of human brain function and behavior. In this work, we show that common task-induced deactivations from rest also occur outside of the DMN as a function of increased task demand. Fifty healthy adult subjects performed two distinct functional magnetic resonance imaging tasks that were designed to reliably map deactivations from a resting baseline. As primary findings, increases in task demand consistently modulated the regional anatomy of DMN deactivation. At high levels of task demand, robust deactivation was observed in non-DMN regions, most notably, the posterior insular cortex. Deactivation of this region was directly implicated in a performance-based analysis of experienced task difficulty. Together, these findings suggest that task-induced deactivations from rest are not limited to the DMN and extend to brain regions typically associated with integrative sensory and interoceptive processes.9 p.application/pdfengcc-by (c) Harrison, Ben J. et al., 2011http://creativecommons.org/licenses/by/3.0/esCognicióMapatge del cervellAssaigs clínicsCognitionBrain mappingClinical trialsinfo:eu-repo/semantics/article6126702013-06-06info:eu-repo/semantics/openAccess21829564