Diaba, FaïzaMontiel Achong, Juan AndrésSerban, GeorgetaBonjoch i Sesé, Josep2019-02-182019-02-182015-01-211523-7060https://hdl.handle.net/2445/128365An unexpected C-C bond cleavage was observed in trichloroacetamide-tethered ketones under amine treatment and exploited to develop a new synthesis of normophans from 4-amidocyclohexanones. The reaction involves an unprecedented intramolecular haloform-type reaction of trichloroacetamides promoted by enamines (generated in situ from ketones) as counter-reagents. The methodology was applied to the synthesis of compounds embodying the 6-azabicyclo[3.2.1]octane framework.4 p.application/pdfeng(c) American Chemical Society , 2015CetonesAminesSíntesi orgànicaReaccions químiquesKetonesAminesOrganic synthesisChemical reactionsinfo:eu-repo/semantics/article6546212019-02-18info:eu-repo/semantics/openAccess26197207