Casas Rodríguez, Rosa M.Domínguez López, InésGalkina, PolinaParilli Moser, IsabellaArancibia Riveros, CamilaMartínez-González, Miguel Ángel, 1957-Salas Salvadó, JordiCorella Piquer, DoloresMalcampo, MireiaMartínez Hernández, José AlfredoTojal Sierra, LucasWärnberg, JuliaVioque, JesúsRomaguera, DoraLópez Miranda, JoséEstruch Riba, RamonTinahones, Francisco J.Santos Lozano, José ManuelSerra Majem, LluísBueno-Cavanillas, AuroraTur, Josep AntoniRubín García, MaríaPintó Sala, XavierFernández-Aranda FDelgado Rodriguez, MiguelBarabash, AnaVidal, JosepVázquez, ClotildeDaimiel, LidiaRos Rahola, EmilioToledo Atucha, EstefaníaAtzeni, AlessandroAsensio, Eva M.Vera, NatàliaGarcía-Ríos, AntonioTorres Collado, LauraPérez-Farinós, NapoleónZulet, M. AngelesChaplin, AliceMartín-Peláez, SandraVaquero Luna, JessicaGómez Pérez, Ana MaríaVázquez Ruiz, ZenaidaShyam, SangheetaOrtega Azorín, CarolinaTalens, NatàliaPeña Orihuela, Patricia J.Oncina Cánovas, AlejandroDiez Espino, JavierBabio, NancyFitó Colomer, MontserratLamuela Raventós, Rosa Ma.2024-03-012024-12-062023-12-071613-4125https://hdl.handle.net/2445/208252<p>Scope: Diets rich in polyphenols has been associated with better cognitive performance. The aim of this study is to</p><p>assess the relationship between microbial phenolic metabolites (MPM) in urine and cognition in the context of an older</p><p>population at high cardiovascular risk.</p><p>Methods and results: A cross-sectional analysis is conducted in 400 individuals of the PREDIMED-Plus study. Liquid</p><p>chromatography coupled to mass spectrometry is used to identify urinaryMPM.Mediterranean diet (MedDiet) adherence</p><p>is estimated with a 17-item questionnaire and cognitive function is evaluated with a battery of neuropsychological tests.</p><p>Multivariable-adjusted linear regression models are fitted to assess the relationship of urinary MPM with the MedDiet</p><p>and cognitive tests. Protocatechuic acid and enterolactone glucuronide are associated with higher adherence to the</p><p>MedDiet. Regarding cognitive function, protocatechuic acid, vanillic acid glucuronide, 3-hydroxybenzoic acid, enterodiol</p><p>glucuronide, and enterolactone glucuronide are directly associated with a global composite score of all the cognitive tests.</p><p>Furthermore, protocatechuic acid and enterolactone glucuronide are associated with higher scores in the Mini-Mental</p><p>State Examination, whereas enterodiol glucuronide is associated with improved Clock Drawing Test scores.</p><p>Conclusions: These results suggest that the MedDiet is linked to MPM associated with better cognitive performance in</p><p>an older population.</p>1 p.application/pdfeng(c) Wiley-VCH, 2023Cuina mediterràniaFenolsSíndrome metabòlicaMediterranean cookingPhenolsMetabolic syndromeinfo:eu-repo/semantics/article7411632024-03-01info:eu-repo/semantics/openAccess