A gram-scale route to phlegmarine alkaloids: rapid total synthesis of (-)-cermizine B

Bradshaw, BenLuque Corredera, CarlosBonjoch i Sesé, Josep2026-01-092026-01-092014-04-031359-7345https://hdl.handle.net/2445/225192The synthesis of the Lycopodium alkaloid ( )-cermizine B (1), which establishes its absolute configuration, is achieved by combining asymmetric organocatalysis and an uninterrupted eight-step reaction sequence, followed by a final reduction step. This ''pot-economy'' strategy provides access to the cis-phlegmarine stereo parent embedded in 1 for the first time, rapidly and on a gram-scale.5 p.application/pdfeng(c) Bradshaw, B. et al., 2014MedicamentsAlcaloidesSíntesi orgànicaDrugsAlkaloidsOrganic synthesisA gram-scale route to phlegmarine alkaloids: rapid total synthesis of (-)-cermizine Binfo:eu-repo/semantics/article6302952026-01-09info:eu-repo/semantics/openAccess