Martín-Peláez, SandraSerra Majem, LluísCano Ibáñez, NaomiMartínez-González, Miguel Ángel, 1957-Salas Salvadó, JordiCorella Piquer, DoloresLassale, CamilleMartínez, J. Alfredo, 1957-Alonso Gómez, Ángel M.Wärnberg, JuliaVioque, JesúsRomaguera, DoraLópez Miranda, JoséEstruch Riba, RamonTinahones, Francisco J.Lapetra, JoséFernández Aranda, FernandoBueno Cavanillas, AuroraTur, Josep A.Martín Sánchez, VicentePintó Sala, XavierDelgado Rodriguez, MiguelMatía Martín, PilarVidal i Cortada, JosepVázquez, ClotildeDaimiel, LidiaRos Rahola, EmilioToledo Atucha, EstefaníaNishi, Stephanie K.Sorlí, José V.Malcampo, MireiaZulet, M. AngelesMoreno Rodríguez, AnaiCueto Galán, RaquelVivancos Aparicio, DiegoColom, AntoniGarcía Ríos, AntonioCasas Rodríguez, Rosa M.Bernal López, M. RosaSantos Lozano, José ManuelVázquez Ruiz, ZenaidaGómez Martínez, CarlosOrtega Azorín, CarolinaDel Val, Jose LuísAbete, ItziarGoikoetxea Bahon, AmaiaPascual, ElenaBecerra Tomás, NereaChillarón, Juan J.Sánchez-Villegas, Almudena2022-11-232022-11-232022-04-131932-6203https://hdl.handle.net/2445/191028Background: Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial. Methods and findings: Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol <160 mg/mL showed higher odds of depression than LR [OR (95% CI) = 1.77 (1.13, 2.77) and 2.83 (1.25, 6.42) respectively)] but those with total cholesterol ≥280 mg/mL showed lower odds of depression than LR [OR (95% CI) = 0.26 (0.07, 0.98) and 0.23 (0.05, 0.95), respectively]. All participants decreased their BDI-II score after 2 years, being the decrease smaller in MR and HR diabetic compared to LR [adjusted mean±SE = -0.52±0.20, -0.41±0.27 and -1.25±0.31 respectively). MR and HR participants with total cholesterol between 240-279 mg/mL showed greater decreases in the BDI-II score compared to LR (adjusted mean±SE = -0.83±0.37, -0.77±0.64 and 0.97±0.52 respectively). Conclusions: Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response. International Standard Randomized Controlled Trial (ISRCTN89898870).18 p.application/pdfengcc-by (c) Martín-Peláez, Sandra et al., 2022https://creativecommons.org/licenses/by/4.0/Malalties cardiovascularsAvaluació del risc per la salutDepressió psíquicaSíndrome metabòlicaColesterolDiabetisCardiovascular diseasesHealth risk assessmentMental depressionMetabolic syndromeCholesterolDiabetesinfo:eu-repo/semantics/article7229892022-11-23info:eu-repo/semantics/openAccess35417452