Hernández Romero, DeliaRiego, EstelaFrancesch, AndrésCuevas, CarmenAlbericio Palomera, FernandoÁlvarez Domingo, Mercedes2014-06-272014-06-272007-07-100040-4020https://hdl.handle.net/2445/55267Herein is described the synthesis of several analogs of the natural product IB-01211 from concatenated azoles, via a biomimetic pathway based on cyclization-oxidation of serine containing peptides combined with the Hantzsch synthesis. The macrocyclization of rigid peptide compounds 1 and 2 to give IB-01211 and its epimer 12b was explored, and the results are compared here to those previously obtained for the macrocyclization of more flexible structures in the syntheses of YM-216391, telomestatin, and IB-01211. Lastly, the preliminary results of anti-tumor activity screening of the synthesized analogs are discussed.9 p.application/pdfeng(c) Elsevier B.V., 2007Productes naturalsPèptidsSíntesi orgànicaCompostos heterocíclicsNatural productsPeptidesOrganic synthesisHeterocyclic compoundsinfo:eu-repo/semantics/article5558782014-06-27info:eu-repo/semantics/openAccess