Papandreou, ChristopherLi, JunLiang, LimingBulló, MònicaZheng, YanRuiz Canela, MiguelYu, EdwardGuasch-Ferré, MartaRazquin, ClaryClish, Clary B.Corella Piquer, DoloresEstruch Riba, RamonRos Rahola, EmilioFitó Colomer, MontserratArós, FernandoSerra Majem, LluísRosique Esteban, NúriaMartínez-González, Miguel Ángel, 1957-Hu, Frank B.Salas Salvadó, Jordi2020-05-262020-05-262019-02-272045-2322https://hdl.handle.net/2445/162521Studies examining associations between purine metabolites and type 2 diabetes (T2D) are limited. We prospectively examined associations between plasma levels of purine metabolites with T2D risk and the modifying effects of transcription factor-7-like-2 (TCF7L2) rs7903146 polymorphism on these associations. This is a case-cohort design study within the PREDIMED study, with 251 incident T2D cases and a random sample of 694 participants (641 non-cases and 53 overlapping cases) without T2D at baseline (median follow-up: 3.8 years). Metabolites were semi-quantitatively profiled with LC-MS/MS. Cox regression analysis revealed that high plasma allantoin levels, including allantoin-to-uric acid ratio and high xanthine-to-hypoxanthine ratio were inversely and positively associated with T2D risk, respectively, independently of classical risk factors. Elevated plasma xanthine and inosine levels were associated with a higher T2D risk in homozygous carriers of the TCF7L2-rs7903146 T-allele. The potential mechanisms linking the aforementioned purine metabolites and T2D risk must be also further investigated.11 p.application/pdfengcc-by (c) Papandreou, Christopher et al., 2019http://creativecommons.org/licenses/by/3.0/esMetabòlitsDiabetis no-insulinodependentPolimorfisme (Cristal·lografia)MetabolitesNon-insulin-dependent diabetesPolymorphism (Crystallography)info:eu-repo/semantics/article6877592020-05-26info:eu-repo/semantics/openAccess30814579