Caro, CarlosDalmases Solé, MarionaFiguerola i Silvestre, AlbertGarcía-Martín, M.L.Pernia Leal, Manuel2020-04-032020-04-032017-04-252040-3364https://hdl.handle.net/2445/154912X-ray computed tomography (CT) is a powerful and widely used medical non-invasive technique that requires intravenously administration of contrast agents to enhance the sensitivity and visualization of soft tissues. In this work, we have developed a novel CT contrast agent based on ternary Ag-Au-Se chalcogenide nanoparticles. A facile and gentle ligand exchange by using a 3 kDa PEGylated ligand with a dithiol dihydrolipoic as an anchor resulted in highly water-soluble and monodisperse nanoparticles. Moreover, the injected PEGylated ternary NPs presented excellent characteristics as a CT contrast agent with high bioavailability, low cytotoxicity and long blood circulation times with slow uptake by the mononuclear phagocyte system, thus being ideal for in vivo imaging.10 p.application/pdfeng(c) Caro, Carlos et al., 2017LligandsNanopartículesTomografiaLigandsNanoparticlesTomographyinfo:eu-repo/semantics/article6799072020-04-03info:eu-repo/semantics/openAccess