Costelli, PaolaCarbó Carbó, NeusTessitore, LucianaBagby, Gregory J.López-Soriano, Francisco J.Argilés Huguet, Josep Ma.Baccino, Francesco M.2009-05-142009-05-1419930021-9738https://hdl.handle.net/2445/8263Rats bearing the Yoshida AH-130 ascites hepatoma showed enhanced fractional rates of protein degradation in gastrocnemius muscle, heart, and liver, while fractional synthesis rates were similar to those in non-tumor bearing rats. This hypercatabolic pattern was associated with marked perturbations of the hormonal homeostasis and presence of tumor necrosis factor in the circulation. The daily administration of a goat anti-murine TNF IgG to tumor-bearing rats decreased protein degradation rates in skeletal muscle, heart, and liver as compared with tumor-bearing rats receiving a nonimmune goat IgG. The anti-TNF treatment was also effective in attenuating early perturbations in insulin and corticosterone homeostasis. Although these results suggest that tumor necrosis factor plays a significant role in mediating the changes in protein turnover and hormone levels elicited by tumor growth, the inability of such treatment to prevent a reduction in body weight implies that other mediators or tumor-related events were also involved.7 p.application/pdfeng(c) The American Society for Clinical Investigation, 1993TumorsNecrosiMúsculsTumor necrosis factorSkeletal muscleProtein turnoverinfo:eu-repo/semantics/article79740info:eu-repo/semantics/openAccess8254032