Performance of the Intergrowth-21st and WHO fetal growth charts for the detection of small-for-gestational age neonates in Latin America

Miranda, JezidMaestre, NataliaPaternina Caicedo, ÁngelParra Saavedra, MiguelCaradeux, JavierSepúlveda Martínez, ÁlvaroPelaez Chomba, MelisaTorres, AndrésParra Cordero, MauroDiaz Corvillón, PilarGallo, Dahiana M.Santacruz, DaríoRodriguez, NicolásSarmiento, AndrésBenavides, Jesús A.Girado, SergioRojas Suarez, José A.Gratacos, EduardFigueras Retuerta, Francesc2024-01-082024-01-082023-01-061879-3479https://hdl.handle.net/2445/205323To evaluate the performance of INTERGROWTH-21st and WHO fetal growth charts to identify small-for-gestational-age (SGA) and fetal growth restriction (FGR) neonates as well as their specific risks for adverse neonatal outcomes.Multicenter cross-sectional study including 67,968 live births from ten maternity units across four Latin American countries. According to each standard, neonates were classified as SGA and FGR (birth weight <10th and <3rd centiles, respectively). The relative risk (RR) and diagnostic performance for a low Apgar score and low ponderal index were calculated for each standard.WHO charts identified more neonates as SGA than INTERGROWTH-21st (13.9% vs. 7%, respectively). Neonates classified as FGRs by both standards had the highest RR for a low Apgar (RR: 5.57; 95% CI: 3.99-7.78), followed by those SGA by both curves (RR: 3.27; 95% CI: 2.52-4.24), while SGAs identified by WHO alone did not have an additional risk (RR: 0.87; 95% CI: 0.55-1.39). Furthermore, the diagnostic odds ratio for a low Apgar was higher when INTERGROWTH-21st was used.In a population from Latin America, the WHO charts seem to identify more SGA neonates, but the diagnostic performance of the INTERGROWTH-21st charts for low Apgar score and low ponderal index is better.This article is protected by copyright. All rights reserved.10 p.application/pdfengcc by-nc-nd (c) Miranda, Jezid et al, 2023http://creativecommons.org/licenses/by-nc-nd/3.0/es/NeonatologiaComposició corporal (Fisiologia)NeonatologyBody composition (Physiology)Performance of the Intergrowth-21st and WHO fetal growth charts for the detection of small-for-gestational age neonates in Latin Americainfo:eu-repo/semantics/article2023-12-14info:eu-repo/semantics/openAccess933671036606760