Yeh, Ta-ChuanLiang, Chih-SungTsai, Chia-KuangSolmi, MarcoLafer, BenyTseng, Ping-TaoHsu, Chih-WeiLin, Pao YenFirth, JosephStubbs, BrendonHassan, LamieceFornaro, MicheleVieta i Pascual, Eduard, 1963-Thompson, TrevorShin, JaeilCarvalho, André F.2022-05-182022-05-182022-02-011661-7827https://hdl.handle.net/2445/185711Introduction In December 2019, the world witnessed the emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which posed an extraordinary threat to global public health and human safety [1]. SARS-CoV-2, a highly contagious and pathogenic virus, rapidly disseminated across the world, causing a pandemic of coronavirus disease 2019 (COVID-19). In addition to pulmonary pathology, COVID-19 is now recognized as a systemic disease associated with a broad spectrum of manifestations (e.g., hematological, cardiovascular, renal, and neuropsychiatric) [2-4]. The mechanisms driving multi-organ damage may involve direct viral infection and toxicity, endothelial cell damage, dysregulated immune response, cytokine storm, and maladaptive functions of the renin-angiotensin-aldosterone system [3,4]. Moreover, accumulating evidence suggests persistent and prolonged effects on multiple organs and the brain after the acute COVID-19 subsides9 p.application/pdfengcc-by (c) Yeh, Ta-Chuan et al., 2022https://creativecommons.org/licenses/by/4.0/COVID-19SARS-CoV-2Salut mentalMalalties del sistema nerviósMalalties mentalsCOVID-19SARS-CoV-2Mental healthNervous system DiseasesMental illnessinfo:eu-repo/semantics/article7185682022-05-18info:eu-repo/semantics/openAccess35162704