Adelfinskaya, O.Terrazas Martínez, MontserratFroeyen, M.Marlière, P.Nauwelaerts, K.Herdewijn, P.2021-07-272021-07-272007-07-250305-1048https://hdl.handle.net/2445/179405Some selected amino acids, in particular L-aspartic acid (L-Asp) and L-histidine (L-His), can function as leaving group during polymerase-catalyzed incorporation of deoxyadenosine monophosphate (dAMP) in DNA. Although L-Asp-dAMP and L-His-dAMP bind, most probably, in a different way in the active site of the enzyme, aspartic acid and histidine can be considered as mimics of the pyrophosphate moiety of deoxyadenosine triphosphate. L-Aspartic acid is more efficient than D-aspartic acid as leaving group. Such P-N conjugates of amino acids and deoxynucleotides provide a novel experimental ground for diversifying nucleic acid metabolism in the field of synthetic biology.13 p.application/pdfengcc-by-nc (c) Adelfinskaya, O. et al., 2007https://creativecommons.org/licenses/by-nc/4.0/ADNAminoàcidsPolímersDNAAmino acidsPolymersinfo:eu-repo/semantics/article7134452021-07-27info:eu-repo/semantics/openAccess17652326