Steyn, AngelaCrowther, Nigel J.Norris, Shane A.Rabionet Janssen, RaquelEstivill, Xavier, 1955-Ramsay, Michèle2020-05-282020-10-042019-10-041750-1911https://hdl.handle.net/2445/162772Aim: Gestational diabetes mellitus (GDM) has been linked with adverse long-term health outcomes for the fetus and mother. These effects may be mediated by epigenetic modifications. Materials & methods: Genome-wide RNA sequencing was performed in placental tissue and maternal blood in six GDM and six non-GDM pregnancies. Promoter region DNA methylation was examined for selected genes and correlated with gene expression to examine an epigenetic modulator mechanism. Results: Reductions of mRNA expression and increases in promoter methylation were observed for G6PD in GDM women, and for genes encoding IGF-binding proteins in GDM-exposed placenta. Conclusion: GDM involves epigenetic attenuation of G6PD, which may lead to hyperglycemia and oxidative stress, and the IGF-axis, which may modulate fetal macrosomia.15 p.application/pdfeng(c) Future Medicine, 2019Diabetis en l'embaràsEpigenèticaDiabetes in pregnancyEpigeneticsinfo:eu-repo/semantics/article6924442020-05-28info:eu-repo/semantics/openAccess