Rovira, XavierTrapero, AnaPittolo, SilviaZussy, CharleineFaucherre, AdèleJopling, ChrisGiraldo, JesúsPin, Jean-PhilippeGorostiza Langa, Pablo IgnacioGoudet, CyrilLlebaria Soldevila, Amadeu2020-04-202020-04-202016-08-18https://hdl.handle.net/2445/156117OptoGluNAM4.1, a negative allosteric modulator (NAM) of metabotropic glutamate receptor 4 (mGlu4) contains a reactive group that covalently binds to the receptor and a blue-light-activated, fast-relaxing azobenzene group that allows reversible receptor activity photocontrol in vitro and in vivo. OptoGluNAM4.1 induces light-dependent behavior in zebrafish and reverses the activity of the mGlu4 agonist LSP4-2022 in a mice model of chronic pain, defining a photopharmacological tool to better elucidate the physiological roles of the mGlu4 receptor in the nervous system.11 p.application/pdfengcc by-nc-nd (c) Elsevier, 2016http://creativecommons.org/licenses/by-nc-nd/3.0/es/Sistema nerviósDolor crònicNervous systemChronic paininfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccess