Giralt Torroella, AlbertBrito, VerónicaPardo Muñoz, MònicaRubio Abejón, Sara EsmeraldaMarion Poll, LucileMartín Ibáñez, RaquelZamora-Moratalla, AlfonsaBosch, CarlesBallesteros, Jesús J.Blasco, EstherGarcía-Torralba, AídaPascual Sánchez, MartaPumarola, MartíAlberch i Vié, Jordi, 1959-Ginés Padrós, SilviaMartín, Eduardo D.Segovia, José CarlosSoriano García, EduardoCanals i Coll, Josep M.2020-03-262020-03-262020-01-010014-4886https://hdl.handle.net/2445/153989Currently, molecular, electrophysiological and structural studies delineate several neural subtypes in the hippocampus. However, the precise developmental mechanisms that lead to this diversity are still unknown. Here we show that alterations in a concrete hippocampal neuronal subpopulation during development specifically affect hippocampal-dependent spatial memory. We observed that the genetic deletion of the transcription factor Helios in mice, which is specifically expressed in developing hippocampal calbindin-positive CA1 pyramidal neurons (CB-CA1-PNs), induces adult alterations affecting spatial memory. In the same mice, CA3-CA1 synaptic plasticity and spine density and morphology in adult CB-CA1-PNs were severely compromised. RNAseq experiments in developing hippocampus identified an aberrant increase on the Visinin-like protein 1 (VSNL1) expression in the hippocampi devoid of Helios. This aberrant increase on VSNL1 levels was localized in the CB-CA1-PNs. Normalization of VSNL1 levels in CB-CA1-PNs devoid of Helios rescued their spine loss in vitro. Our study identifies a novel and specific developmental molecular pathway involved in the maturation and function of a CA1 pyramidal neuronal subtype.18 p.application/pdfengcc by-nc-nd (c) Giralt Torroella et al., 2020http://creativecommons.org/licenses/by-nc-nd/3.0/esNeurociènciesNeurosciencesinfo:eu-repo/semantics/article6938902020-03-26info:eu-repo/semantics/openAccess31712124