Valle-Hita, CristinaBecerra Tomás, NereaDíaz López, AndrésVázquez Ruiz, ZenaidaMegías, IsabelCorella Piquer, DoloresGoday Arnó, AlbertMartínez, J. Alfredo, 1957-Alonso Gómez, Ángel M.Wärnberg, JuliaVioque, JesúsRomaguera, DoraLópez Miranda, JoséEstruch Riba, RamonTinahones, Francisco J.Lapetra, JoséSerra Majem, LluísBueno-Cavanillas, AuroraTur, Josep AntoniMartín-Sánchez, VicentePintó Sala, XavierGaforio, José J.Matía Martín, PilarVidal i Cortada, JosepAmengual-Galbarte, AngelaDaimiel, LidiaRos Rahola, EmilioGarcia-Arellano, AnaBarragán, RocíoFitó Colomer, MontserratPeña Orihuela, Patricia J.Asencio, AlbertoGómez Gracia, EnriqueMartinez Urbistondo, DiegoMorey, MargaCasas Rodríguez, Rosa M.Garrido-Garrido, Eva MariaTojal Sierra, LucasDamas-Fuentes, MiguelGoñi, EstibalizOrtega Azorín, CarolinaCastañer, OlgaGarcia-Rios, AntonioGisbert Sellés, CristinaSayón Orea, CarmenSchröder, Helmut, 1958-Salas Salvadó, JordiBabio, Nancy2023-01-172023-01-172022-09-302296-861Xhttps://hdl.handle.net/2445/192271Background: Diets high in acid load may contribute to kidney function impairment. This study aimed to investigate the association between dietary acid load and 1-year changes in glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (UACR). Methods: Older adults with overweight/obesity and metabolic syndrome (mean age 65 ± 5 years, 48% women) from the PREDIMED-Plus study who had available data on eGFR (n = 5,874) or UACR (n = 3,639) at baseline and after 1 year of follow-up were included in this prospective analysis. Dietary acid load was estimated as potential renal acid load (PRAL) and net endogenous acid production (NEAP) at baseline from a food frequency questionnaire. Linear and logistic regression models were fitted to evaluate the associations between baseline tertiles of dietary acid load and kidney function outcomes. One year-changes in eGFR and UACR were set as the primary outcomes. We secondarily assessed ≥ 10% eGFR decline or ≥10% UACR increase. Results: After multiple adjustments, individuals in the highest tertile of PRAL or NEAP showed higher one-year changes in eGFR (PRAL, β: -0.64 ml/min/1.73 m2; 95% CI: -1.21 to -0.08 and NEAP, β: -0.56 ml/min/1.73 m2; 95% CI: -1.13 to 0.01) compared to those in the lowest category. No associations with changes in UACR were found. Participants with higher levels of PRAL and NEAP had significantly higher odds of developing ≥10% eGFR decline (PRAL, OR: 1.28; 95% CI: 1.07-1.54 and NEAP, OR: 1.24; 95% CI: 1.03-1.50) and ≥10 % UACR increase (PRAL, OR: 1.23; 95% CI: 1.04-1.46) compared to individuals with lower dietary acid load. Conclusions: Higher PRAL and NEAP were associated with worse kidney function after 1 year of follow-up as measured by eGFR and UACR markers in an older Spanish population with overweight/obesity and metabolic syndrome. Keywords: albuminuria; chronic kidney disease (CKD); dietary acid load; glomerular filtration rate (GFR); kidney function; net endogenous acid production (NEAP); potential renal acid load (PRAL); renal nutrition.13 p.application/pdfengcc-by (c) Valle-Hita, Cristina et al., 2022https://creativecommons.org/licenses/by/4.0/Malalties del ronyóSíndrome metabòlicaNutricióKidney diseasesMetabolic syndromeNutritioninfo:eu-repo/semantics/article7259252023-01-17info:eu-repo/semantics/openAccess933134936245494