Inguanzo, AnnaPoulakis, KonstantinosMohanty, RosaleenaSchwarz, Christopher G.Przybelski, Scott A.Diaz Galvan, PatriciaLowe, Val J.Boeve, Bradley F.Lemstra, Afina W.van De Beek, Marleenvan der Flier, WiesjeBarkhof, FrederikBlanc, FrederikLoureiro de Sousa, PauloPhilippi, NathalieCretin, BenjaminDemuynck, CatherineNedelska, ZuzanaHort, JakubSegura, BarbaraJunqué i Plaja, Carme, 1955-Oppedal, KetilAarsland, DagWestman, EricKantarci, KejalFerreira, Daniel2023-07-262023-07-262023-01-202373-8057https://hdl.handle.net/2445/201183Dementia with Lewy bodies (DLB) is a neurodegenerative disorder with a wide heterogeneity of symptoms, which suggests the existence of different subtypes. We used data-driven analysis of magnetic resonance imaging (MRI) data to investigate DLB subtypes. We included 165 DLB from the Mayo Clinic and 3 centers from the European DLB consortium and performed a hierarchical cluster analysis to identify subtypes based on gray matter (GM) volumes. To characterize the subtypes, we used demographic and clinical data, as well as β-amyloid, tau, and cerebrovascular biomarkers at baseline, and cognitive decline over three years. We identified 3 subtypes: an older subtype with reduced cortical GM volumes, worse cognition, and faster cognitive decline (n = 49, 30%); a subtype with low GM volumes in fronto-occipital regions (n = 76, 46%); and a subtype of younger patients with the highest cortical GM volumes, proportionally lower GM volumes in basal ganglia and the highest frequency of cognitive fluctuations (n = 40, 24%). This study shows the existence of MRI subtypes in DLB, which may have implications for clinical workout, research, and therapeutic decisions.7 p.application/pdfengcc-by (c) Inguanzo, Anna et al., 2023https://creativecommons.org/licenses/by/4.0/Malalties neurodegenerativesDemència amb cossos de LewyAlfa-sinucleïnaImatges per ressonància magnèticaAnàlisi de conglomeratsNeurodegenerative DiseasesLewy body dementiaAlpha-synucleinMagnetic resonance imagingCluster analysisinfo:eu-repo/semantics/article7381032023-07-26info:eu-repo/semantics/openAccess36670121