Badia-Cebada, LaiaPeñafiel, JudithLópez-Contreras, JoaquínPomar, VirginiaMartínez, José AntonioSantana, GerminaCuquet, JordiMontero, Maria M.Hidalgo-López, CarlotaAndrés, MartaGimenez, MontserratQuesada, María DoloresVaqué, MontserratIftimie, SimonaGudiol González, CarlotaPerez, RafelColoma, AnnaMarrón, AnnaBarrufet, PilarMarimon, MariloLérida, AnaClarós, MercèRamírez-Hidalgo, Maria FernandaGarcia Pardo, GracianoMartinez, M. JesúsChamarro, Elena LourdesJiménez-Martínez, EmiliHornero, AnaLimón, EnriqueLópez, MariaCalbo, EstherPujol, MiquelGasch, Oriol2022-05-202023-05-192022-05-190195-6701https://hdl.handle.net/2445/185883Background: The incidence of catheter-related bloodstream infections (CRBSI) has fallen over the last decade, especially in intensive care units (ICUs). Aim: to assess the existence of concomitant trends in outcomes and to analyse the current risk factors for mortality. Methods: A multicentre retrospective cohort study was conducted at 24 Catalan hospitals participating in the Surveillance of healthcare associated infections in Catalonia (VINCat). All hospital-acquired CRBSI episodes diagnosed from January 2010 to December 2019 were included. A common protocol including epidemiological, clinical and microbiological data was prospectively completed. Mortality at days after bacteraemia onset was analysed using the Cox regression model. Findings: Over the study period, 4,795 episodes of CRBSI were diagnosed. Among them, 75% were acquired in conventional wards and central venous catheters were the most frequently involved (61%). The 30-day mortality rate was 13.8%, presenting a significant downward trend over the study period: from 17.9% in 2010 to 10.6% in 2019 (HR 0.95 [0.92-0.98]). The multivariate analysis identified age (HR 1.03 83 [1.02-1.04]), femoral catheter (HR 1.78 [1.33-2.38]), medical ward acquisition (HR 2.07 [1.62-2.65] and ICU acquisition (HR 3.45 [2.7-4.41]), S. aureus (HR 1.59 [1.27-1.99]) and Candida sp. (HR 2.19 [1.64-2.94]) as risk factors for mortality while the mortality rate associated with episodes originating in peripheral catheters was significantly lower (HR 0.69 [0.54-0.88]). Conclusions: Mortality associated with CRBSI has fallen in recent years but remains high. Intervention programs should focus especially on ICUs and medical wards, where incidence and mortality rates are highest.28 p.application/pdfengcc-by-nc-nd (c) Elsevier, 2022https://creativecommons.org/licenses/by-nc-nd/4.0/MortalitatCatètersInfeccionsHospitalsMortalityCathetersInfectionsHospitalsinfo:eu-repo/semantics/article7234882022-05-20info:eu-repo/semantics/openAccess