Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate

Maga, GiovanniRadi, MarcoZanoli, SamanthaManetti, FabrizioCancio, ReynelHübscher, UlrichSpadari, SilvioFalciani, ChiaraTerrazas Martínez, MontserratVilarrasa i Llorens, JaumeBotta, Maurizio2022-03-042022-03-0420071433-7851https://hdl.handle.net/2445/183770How odd! A new class of non-nucleoside reverse transcriptase inhibitors with a 6-vinylpyrimidine scaffold (1) has been found to inhibit HIV-1 reverse transcriptase (RT) by competition with the nucleotide substrate after binding to the non-nucleoside inhibitor binding pocket of the enzyme. Molecular modeling studies have been performed to elucidate their peculiar behavior.4 p.application/pdfeng(c) Wiley-VCH, 2007NucleòsidsPirimidinesRadiocristal·lografiaNucleosidesPyrimidinesX-ray crystallographyDiscovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrateinfo:eu-repo/semantics/article7134522022-03-04info:eu-repo/semantics/openAccess