Calon, AlexandreEspinet, ElisaPalomo Ponce, SergioTauriello, Daniele V. F.Iglesias, MarCéspedes, MaríaSevillano, MartaNadal, CristinaJung, PeterZhang, XiangByrom, DanielRiera i Escalé, AntoniRossell, DavidMangues, RamonMassagué i Solé, Joan, 1953-Sancho, ElenaBatlle, Eduard2022-02-242022-02-242014-05-052331-8325https://hdl.handle.net/2445/183522Metastasis depends on a gene program expressed by the tumor microenvironment upon TGF-beta stimulation. CRC (Colorectal cancer) cell lines did not induce robust stromal TGF- beta responses when injected into nude mice as shown by lack of p- SMAD2 accumulation in tumor-associated stromal cells. To enforce high TGF-beta signaling in xenografts, we engineered CRC cell lines to secrete active TGF-beta. Subcutaneous tumors obtained from HT29-M6TGF-β, KM12L4aTGF-β cells and SW48TGF-β cells contained abundant p-SMAD2+ stromal cells.4 p.application/pdfeng(c) Bio-protocol LLC, 2014Càncer colorectalMetàstasiExpressió gènicaColorectal cancerMetastasisGene expressioninfo:eu-repo/semantics/article2022-02-24info:eu-repo/semantics/openAccess6544613