Misfolded α-Synuclein Assessment in the Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior Disorder

Iranzo, AlexMammana, AngelaMuñoz Lopetegi, AmaiaDellavalle, SofiaMayà Casalprim, GerardRossi, MarcelloSerradell, MónicaBaiardi, SimoneArqueros, AuroraQuadalti, CorinnePerissinotti, AndrésRuggeri, EdoardoSantamaria Cano, JoanGaig Ventura, CarlesParchi, Piero2025-04-032025-04-032023-05-020028-3878https://hdl.handle.net/2445/220233Real-time quaking-induced conversion (RT-QuIC) assay detects misfolded α-synuclein (AS) in the skin and CSF of patients with the synucleinopathies Parkinson disease and dementia with Lewy bodies. Isolated REM sleep behavior disorder (IRBD) constitutes the prodromal stage of these synucleinopathies. We aimed to compare the ability of RT-QuIC to identify AS in the skin and CSF of patients with IRBD.11 p.application/pdfeng(c) American Academy of Neurology, 2023Trastorns del sonDemència amb cossos de LewyMalaltia de ParkinsonSleep disordersLewy body dementiaParkinson's diseaseMisfolded α-Synuclein Assessment in the Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior Disorderinfo:eu-repo/semantics/article7561642025-04-03info:eu-repo/semantics/openAccess36931726