Hernández Romero, DeliaAltuna, MartaCuevas, CarmenAligué i Alemany, Rosa MariaAlbericio Palomera, FernandoÁlvarez Domingo, Mercedes2014-07-182014-07-182008-09-030022-2623https://hdl.handle.net/2445/56045Several analogs of the cytotoxic thiopeptide IB-01211 or Mechercharmycin A (1) have been synthetized. The cytotoxicity of 1 and the synthetized analogs was evaluated against a panel of three human tumor cell lines. Thiopeptide 1 and the most active derivatives, 2 and 3c, were chosen for further studies like effects on cell cycle progression and induction of apoptosis. Interestingly, the inhibition of cell division and activation of a programmed cell death by apoptosis was detected.9 p.application/pdfeng(c) American Chemical Society , 2008Compostos heterocíclicsMedicaments antineoplàsticsSíntesi de pèptidsEspectroscòpia de ressonància magnètica nuclearHeterocyclic compoundsAntineoplastic agentsPeptide synthesisNuclear magnetic resonance spectroscopyinfo:eu-repo/semantics/article5649582014-07-18info:eu-repo/semantics/openAccess