Fibrinogen-Derived γ377-395 Peptide Improves Cognitive Performance and Reduces Amyloid-β Deposition, without Altering Inflammation, in AβPP/PS1 Mice

Aso Pérez, EsterSerrano, Antonio L.Muñoz Cánoves, Pura, 1962-Ferrer, Isidro (Ferrer Abizanda)2020-12-212020-12-212015-04-211387-2877https://hdl.handle.net/2445/172893Fibrinogen has emerged as a promising therapeutic target against Alzheimer's disease because of its dual role in altered vascular function and amyloid-β aggregation. Here we provide evidence regarding cognitive improvement and reduction of brain parenchyma amyloid-β deposition in AβPP/PS1 mice after treatment for one month with the fibrinogen-blocking peptide Fibγ377-395. No alteration in glial response or other neuroinflammatory markers was observed in the cortex of treated animals. Considering these results and the fact that Fibγ377-395 does not affect coagulation function, this peptide could be considered as a promising and safe candidate for chronic treatment of Alzheimer's disease.10 p.application/pdfeng(c) Aso Pérez, Ester et al., 2015Ratolins (Animals de laboratori)Malaltia d'AlzheimerAmiloïdosiFibrinogenInflamacióMice (Laboratory animals)Alzheimer's diseaseAmyloidosisFibrinogenInflammationFibrinogen-Derived γ377-395 Peptide Improves Cognitive Performance and Reduces Amyloid-β Deposition, without Altering Inflammation, in AβPP/PS1 Miceinfo:eu-repo/semantics/article6977622020-12-21info:eu-repo/semantics/openAccess