Gómez Valenzuela, FernánEscobar, EnricoPérez Tomás, RicardoMontecinos, Viviana P.2021-07-122021-07-122021-06-10https://hdl.handle.net/2445/178974Microbial infections are a major public health concern. Antimicrobial peptides (AMPs) have been demonstrated to be a plausible alternative to the current arsenal of drugs that has become inefficient due to multidrug resistance. Herein we describe a new AMP family, namely the super-cationic peptide dendrimers (SCPDs). Although all members of the series exert some antibacterial activity, we propose that special attention should be given to (KLK)2KLLKLL-NH2 (G1KLK-L2KL2), which shows selectivity for Gram-negative bacteria and virtually no cytotoxicity in HepG2 and HEK293. These results reinforce the validity of the SCPD family as a valuable class of AMP and support G1KLK-L2KL2 as a strong lead candidate for the future development of an antibacterial agent against Gram-negative bacteria.16 p.application/pdfengcc by (c) Gómez Valenzuela, Fernán et al., 2021http://creativecommons.org/licenses/by/3.0/es/CàncerInflamacióFenotipCancerInflammationPhenotypeinfo:eu-repo/semantics/article2021-07-09info:eu-repo/semantics/openAccess34178680