Canals, AlbertArribas Bosacoma, RaquelAlbericio Palomera, FernandoÁlvarez Domingo, MercedesAymamí, JoanColl, Miquel2019-03-292019-03-292017-01-042045-2322https://hdl.handle.net/2445/131078Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DNA forming a pseudo-Holliday junction shows that this compound can also contribute, through intercalative binding, to either the formation or stabilization of multi-stranded DNA forms.5 p.application/pdfengcc-by (c) Canals, Albert et al., 2017http://creativecommons.org/licenses/by/3.0/esAlcaloidesMedicaments antineoplàsticsADNMedicaments antivíricsAlkaloidsAntineoplastic agentsDNAAntiviral agentsinfo:eu-repo/semantics/article6665802019-03-29info:eu-repo/semantics/openAccess28051169