Ayesa-Arriola, RosaLópez-Díaz, ÁlvaroRuiz-Veguilla, MiguelLeza, Juan CarlosFañanás Saura, LourdesCrespo-Facorro, Benedicto2022-04-292022-04-292021-011888-9891https://hdl.handle.net/2445/185257Study of the effects of prenatal maternal infection on early offspring brain development has long attracted the interest and endeavors of clinicians and neuroscientists.1 Early reports on large-scale ecological data and further birth cohort studies analyzing biomarkers in pregnancy and early life of offspring have yielded evidence that in-utero exposure to infection increases neuropsychiatric disorder risk, particularly schizophrenia and autism spectrum disorders.2, 3, 4 The main hypothesis derived from these studies is that activation of immune-inflammatory pathways during maternal infection may result in abnormal fetal brain development.5 However, such a hypothesis requires detailed testing to reveal the pathogenic and pathophysiological mechanisms behind these neurodevelopmental alterations.3 p.application/pdfengcc-by-nc-nd (c) Sociedad Española de Psiquiatría y Sociedad Española de Psiquiatría Biológica, 2021https://creativecommons.org/licenses/by-nc-nd/4.0/COVID-19Malalties mentalsCOVID-19Mental illnessinfo:eu-repo/semantics/article7106862022-04-29info:eu-repo/semantics/openAccess