Bonanad, ClaraGarcía Blas, SergioTorres Llergo, JavierFernández Olmo, RosaDíez Villanueva, PabloAriza Solé, AlbertMartínez Sellés, ManuelRaposeiras Roubín, SergioAyesta, AnaBertomeu González, VicenteTarazona Santabalbina, FranciscoFacila, LorenzoVivas, DavidGabaldón Pérez, AnaBodi, VicenteNuñez, JulioCordero, Alberto2022-03-082022-03-082021-11-122077-0383https://hdl.handle.net/2445/183879Direct oral anticoagulants (DOACs) have been demonstrated to be more effective and safer than vitamin-K antagonist (VKA) for stroke prevention in patients with nonvalvular atrial fibrillation (AF). This meta-analysis aims to assess the effect of DOACS vs. VKA in patients ≥ 80 and AF. Primary endpoints were stroke or systemic embolism and all-cause death. Secondary endpoints included major bleeding, intracranial bleeding, and gastrointestinal bleeding. A random-effects model was selected due to significant heterogeneity. A total of 147,067 patients from 16 studies were included, 71,913 (48.90%) treated with DOACs and 75,154 with VKA (51.10%). The stroke rate was significantly lower in DOACs group compared with warfarin group (Relative risk (RR): 0.72; 95% confidence interval (CI): 0.63-0.82; p < 0.001). All-cause mortality was significantly lower in DOACs group compared with warfarin group (RR: 0.82; 95% CI: 0.70-0.96; p = 0.012). Compared to warfarin, DOACs were not associated with reductions in major bleeding (RR: 0.85, 95% CI 0.69-1.04; p = 0.108) or gastrointestinal bleeding risk (RR: 1.08, 95% CI 0.76-1.53; p = 0.678) but a 43% reduction of intracranial bleeding (RR: 0.47, IC 95% 0.36-0.60; p < 0.001) was observed. Our meta-analysis demonstrates that DOACs are effective and safe with statistical superiority when compared with warfarin in octogenarians with AF.11 p.application/pdfengcc-by (c) Bonanad, Clara et al., 2021https://creativecommons.org/licenses/by/4.0/Persones gransMalalties coronàriesAnticoagulants (Medicina)Infart de miocardiOlder peopleCoronary diseasesAnticoagulants (Medicine)Myocardial infarctioninfo:eu-repo/semantics/article7205012022-03-08info:eu-repo/semantics/openAccess