Mao, XiaomanCalero Pérez, PilarMontpeyó, DavidBruna, JordiYuste, Victor J.Candiota, Ana PaulaLorenzo, JuliaNovio, FernandoRuiz Molina, Daniel2022-04-282022-04-282022-04-052079-4991https://hdl.handle.net/2445/185201Cisplatin has been described as a potent anticancer agent for decades. However, in the case of glioblastomas, it is only considered a rescue treatment applied after the failure of second-line treatments. Herein, based on the versatility offered by coordination chemistry, we engineered nanoparticles by reaction of a platinum (IV) prodrug and iron metal ions showing in vitro dual pH- and redox-sensitivity, controlled release and comparable cytotoxicity to cisplatin against HeLa and GL261 cells. In vivo intranasal administration in orthotopic preclinical GL261 glioblastoma tumor-bearing mice demonstrated increased accumulation of platinum in tumors, leading in some cases to complete cure and prolonged survival of the tested cohort. This was corroborated by a magnetic resonance imaging follow-up, thus opening new opportunities for intranasal glioblastoma therapies while minimizing side effects. The findings derived from this research showed the potentiality of this approach as a novel therapy for glioblastoma treatment.22 p.application/pdfengcc by (c) Mao, Xiaoman et al, 2022http://creativecommons.org/licenses/by/3.0/es/GliomaNanopartículesGliomasNanoparticlesinfo:eu-repo/semantics/article2022-04-28info:eu-repo/semantics/openAccess35407338