Gomez, JordiSagués i Mestre, FrancescReigada Sanz, Ramon2011-07-072011-07-0720081063-651Xhttps://hdl.handle.net/2445/18920Lipid rafts, defined as domains rich in cholesterol and sphingolipids, are involved in many important plasma membrane functions. Recent studies suggest that the way cells handle membrane cholesterol is fundamental in the formation of such lateral heterogeneities. We propose to model the plasma membrane as a nonequilibrium phase-separating system where cholesterol is dynamically incorporated and released. The model shows how cellular regulation of membrane cholesterol may determine the nanoscale lipid organization when the lipid mixture is close to a phase separation boundary, providing a plausible mechanism for raft formation in vivo.5 p.application/pdfeng(c) American Physical Society, 2008BiofísicaFísica mèdicaQuímica físicaColesterolMembranes cel·lularsBiophysicsMedical physicsPhysical chemistryCholesterolCell membranesinfo:eu-repo/semantics/article558966info:eu-repo/semantics/openAccess