Agramunt, JordiGinesi, RebeccaPedroso Muller, EnriqueGrandas Sagarra, Anna2020-05-182021-04-222020-04-220022-3263https://hdl.handle.net/2445/160840Oligonucleotides, peptides, and peptide nucleic acids incorporating 7-oxanorbornene as a dienophile were reacted with tetrazines linked to either a peptide, d-biotin, BODIPY, or N-acetyl-d-galactosamine. The inverse electron-demand Diels-Alder (IEDDA) cycloaddition, which was performed overnight at 37 °C, in all cases furnished the target conjugate in good yields. IEDDA reactions with 7-oxanorbornenes produce a lower number of stereoisomers than that of IEDDA cycloadditions with other dienophiles.12 p.application/pdfeng(c) American Chemical Society , 2020Solucions (Química)PèptidsProteïnesBiopolímersDissolventsSolution (Chemistry)PeptidesProteinsBiopolymersSolventsinfo:eu-repo/semantics/article7003462020-05-18info:eu-repo/semantics/openAccess