Hüll, KatharinaFernández Dueñas, VíctorSchönberger, MatthiasLópez-Cano, MarcTrauner, DirkCiruela Alférez, Francisco2023-03-082023-03-082021-12-011043-1802https://hdl.handle.net/2445/194890Adenosine receptors (ARs) play many important roles in physiology and have been recognized as potential targets for pain relief. Here, we introduce three photoswitchable adenosine derivatives that function as light-dependent agonists for ARs and confer optical control to these G protein-coupled receptors. One of our compounds, AzoAdenosine-3, was evaluated in the classical formalin model of pain. The molecule, active in the dark, was not metabolized by adenosine deaminase and effectively reduced pain perception in a light-dependent manner. These antinociceptive effects suggested a major role for A1R and A3R in peripheralmediated pain sensitization, whereas an average adenosine-mediated antinociceptive effect will be facilitated by A2AR and A2BR. Our results demonstrate that a photoswitchable adenosine derivative can be used to map the contribution of ARs mediating analgesia in vivo.5 p.application/pdfengcc by (c) Hüll, Katharina et al., 2021https://creativecommons.org/licenses/by/4.0/AdenosinaTractament del dolorFisiologiaAdenosinePain treatmentPhysiologyinfo:eu-repo/semantics/article7149612023-03-08info:eu-repo/semantics/openAccess34448572