López Vicario, CristinaRius, BibianaAlcaraz-Quiles, JoséGonzález Périz, AnaMartínez Puchol, Ana IsabelCasulleras, MireiaDuran Güell, MartaIbarzabal, AinitzeCorcelles Codina, RicardLaguna Fernández, AndrésBäck, MagnusTitos Rodríguez, EstherClària i Enrich, Joan2018-11-162018-11-162017-11-162045-2322https://hdl.handle.net/2445/126199Obesity comorbidities are closely associated with chronic low-grade adipose tissue inflammation. A number of SNPs associated with inflammation has been identified, underscoring the impact of genetic determinants on this process. Here, we screened SNPs in genes with pro-inflammatory (IL-1 beta, IL-6, STAT3 and JAK2), anti-inflammatory (IL-10 and SOCS3) and pro-resolving (ERV1/ChemR23) properties in 101 obese and 99 non-obese individuals. Among the SNPs analyzed, we identified that individuals carrying a C allele in the rs1878022 polymorphism of the ERV1/ChemR23 gene, which encodes for the receptor of the pro-resolving mediator RvE1, had increased ERV1/ChemR23 protein expression and reduced levels of the inflammatory cytokine IL-6 in adipose tissue. Moreover, patients carrying the C allele in homozygosity had lower plasma levels of IL-6, IFN-alpha 2, IL-15, IL-1ra, IL-10, GM-CSF, G-CSF and VEGF and enhanced leukocyte responsiveness to RvE1. C-carriers also exhibited decreased TAG to HDL ratio, a surrogate marker of insulin resistance and a predictor of incident fatty liver. Finally, we confirmed in vivo that the ERV1/ChemR23 receptor regulates systemic and tissue inflammation since mice lacking ERV1/ChemR23 expression showed increased IL-6 levels in adipose tissue and peritoneal macrophages. Together, our study identified an ERV1/ChemR23 variant that protects patients with obesity from excessive inflammatory burden.11 p.application/pdfengcc-by (c) López-Vicario, Cristina et al., 2017http://creativecommons.org/licenses/by/3.0/esTeixit adipósObesitat mòrbidaInflamacióComorbiditatPolimorfisme genèticAdipose tissuesMorbid obesityInflammationComorbidityGenetic polymorphismsAssociation of a variant in the gene encoding for ERV1/ChemR23 with reduced inflammation in visceral adipose tissue from morbidly obese individualsinfo:eu-repo/semantics/article6757302018-11-16info:eu-repo/semantics/openAccess29146976