Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas

Subirós Funosas, RamonCheuk Lam Ho, VivianBarth, Nicole D.Mendive Tapia, LorenaPappalardo, MorenaBarril Alonso, XavierMa, RuoyuZhang, Cheng-BinQian, Bin-ZhiSintes Marcos, MiquelGhashghaei, OuldouzLavilla Grífols, RodolfoVendrell, Marc2021-07-222021-07-222020-01-202041-6520https://hdl.handle.net/2445/179354Keratin 1 (KRT1) is overexpressed in squamous carcinomas and associated with aggressive pathologies in breast cancer. Herein we report the design and preparation of the first Trp-based red fluorogenic amino acid, which is synthetically accessible in a few steps and displays excellent photophysical properties, and its application in a minimally-disruptive labelling strategy to prepare a new fluorogenic cyclopeptide for imaging of KRT1+ cells in whole intact tumour tissues.7 p.application/pdfengcc-by (c) Subirós Funosas, Ramon et al., 2020http://creativecommons.org/licenses/by/3.0/es/PèptidsAminoàcidsApoptosiPeptidesAmino acidsApoptosisFluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomasinfo:eu-repo/semantics/article6951282021-07-22info:eu-repo/semantics/openAccess34123261