Recasens Álvarez, CarlesFerreira, AnaMilán, Marco2017-01-162017-01-162017-01-032041-1723https://hdl.handle.net/2445/105644A stable pool of morphogen-producing cells is critical for the development of any organ or tissue. Here we present evidence that JAK/STAT signalling in the Drosophila wing promotes the cycling and survival of Hedgehog-producing cells, thereby allowing the stable localization of the nearby BMP/Dpp-organizing centre in the developing wing appendage. We identify the inhibitor of apoptosis dIAP1 and Cyclin A as two critical genes regulated by JAK/STAT and contributing to the growth of the Hedgehog-expressing cell population. We also unravel an early role of JAK/STAT in guaranteeing Wingless-mediated appendage specification, and a later one in restricting the Dpp-organizing activity to the appendage itself. These results unveil a fundamental role of the conserved JAK/STAT pathway in limb specification and growth by regulating morphogen production and signalling, and a function of pro-survival cues and mitogenic signals in the regulation of the pool of morphogen-producing cells in a developing organ.14 p.application/pdfengcc by (c) Recasens et al., 2017http://creativecommons.org/licenses/by/3.0/es/MorfogènesiDrosòfilaMorphogenesisDrosophilainfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1038/ncomms138152017-01-16info:eu-repo/semantics/openAccess28045022