Martínez-Moreno, Jose M.Mela, VirginiaAgüera, ZaidaAlvarez-Bermudez, Maria D.Martín-Reyes, FloresGranero, RoserSánchez-García, AnaOliva-Olivera, WilfredoTomé, MonicaMoreno-Ruiz, Francisco J.Soler-Humanes, RocíoFernández-Serrano, Jose L.Sánchez-Gallegos, PilarSancho-Marín, RaquelFernández Aranda, FernandoGarcía-Fuentes, EduardoTinahones, Francisco J.Garrido-Sánchez, Lourdes2024-03-272024-03-272023-09-222072-6643https://hdl.handle.net/2445/209237Background: There are conflicting results on whether weight loss after bariatric surgery (BS) might be associated with quality of life (QoL)/depressive symptomatology. We aim to determine whether BS outcomes are associated with QoL/depressive symptomatology in studied patients at the 8-year follow-up after BS, as well as their relationship with different serum proteins and miRNAs. Methods: A total of 53 patients with class III obesity who underwent BS, and then classified into "good responders" and "non-responders" depending on the percentage of excess weight lost (%EWL) 8 years after BS (%EWL ≥ 50% and %EWL < 50%, respectively), were included. Basal serum miRNAs and different proteins were analysed, and patients completed tests to evaluate QoL/depressive symptomatology at 8 years after BS. Results: The good responders group showed higher scores on SF-36 scales of physical functioning, role functioning-physical, role functioning-emotional, body pain and global general health compared with the non-responders. The expression of hsa-miR-101-3p, hsa-miR-15a-5p, hsa-miR-29c-3p, hsa-miR-144-3p and hsa-miR-19b-3p were lower in non-responders. Hsa-miR-19b-3p was the variable associated with the response to BS in a logistic regression model. Conclusions: The mental health of patients after BS is limited by the success of the intervention. In addition, the expression of basal serum miRNAs related to depression/anxiety could predict the success of BS.17 p.application/pdfengcc-by (c) Mela, V. et al., 2023http://creativecommons.org/licenses/by/4.0/ObesitatCirurgia de l'obesitatDepressió psíquicaObesityObesity surgeryMental depressioninfo:eu-repo/semantics/article7398992024-03-27info:eu-repo/semantics/openAccess37836393