Mir Morro, BartomeuSolés, X.González, CarlosEscaja Sánchez, Nuria2017-06-142017-06-142017-06-052045-2322https://hdl.handle.net/2445/112375Incorporation of pseudoisocytidine (psC), a neutral analogue of protonated cytidine, in i-motifs has been studied by spectroscopic methods. Our results show that neutral psC:C base pairs can stabilize i-motifs at neutral pH, but the stabilization only occurs when psC:C base pairs are located at the ends of intercalated C:C+ stacks. When psC occupies central positions, the resulting i-motifs are only observed at low pH and psC:C+ or psC:psC+ hemiprotonated base pairs are formed instead of their neutral analogs. Overall, our results suggest that positively charged base pairs are necessary to stabilize this non-canonical DNA structure.8 p.application/pdfengcc-by (c) Mir Morro, Bartomeu et al., 2017http://creativecommons.org/licenses/by/3.0/esÀcids nucleicsCitidina difosfat de colinaOligonucleòtidsNucleic acidsCytidine diphosphate cholineOligonucleotidesinfo:eu-repo/semantics/article6720992017-06-14info:eu-repo/semantics/openAccess28584239