Solé Arjó, DanielPérez Janer, FerranGarcía-Rodeja Navarro, YagoFernández Cadenas, Israel2019-02-012019-02-012017-01-031434-193Xhttps://hdl.handle.net/2445/127810Sulfonates, sulfonamides, and phosphonates have proven useful nucleophiles for palladium‐catalyzed intramolecular α‐arylation reactions leading to tetrahydroisoquinolines. Although the sulfonate α‐arylation reaction can be successfully combined in a domino process with a broad range of Michael acceptors, only vinyl sulfones can be used in Michael additions when starting from sulfonamides. No domino process was developed with the phosphonate derivative. DFT calculations were carried out to gain more insights into the experimental differences observed in the reactions involving these substrates.7 p.application/pdfeng(c) Wiley-VCH, 2017Pal·ladi (Element químic)CatàlisiSulfamidesTeoria del funcional de densitatSíntesi orgànicaPalladiumCatalysisSulfonamidesDensity functionalsOrganic synthesisinfo:eu-repo/semantics/article6674232019-02-01info:eu-repo/semantics/openAccess