Subirats i Vila, XavierJusticia, AltheaRosés Pascual, Martí2019-01-282020-08-082018-08-080021-9673https://hdl.handle.net/2445/127666A homologous series approach derived from the Abraham's solvation model was developed for the determination of hold-up times. Firstly, it was tested from reversed-phase liquid chromatography data obtained in the literature involving several series of homologues, followed by its application in a polymeric zwitterionic HILIC column using two different homologous series (n-alkyl benzenes and n-alkyl phenones). Acetonitrile and methanol were selected as organic modifiers in a composition range between 80% and 100% in volume. Results obtained for both series were consistent, and hold-up times were found to be strongly dependent on the water content and the organic modifier nature of the mobile phase.9 p.application/pdfengcc-by-nc-nd (c) Elsevier B.V., 2018http://creativecommons.org/licenses/by-nc-nd/3.0/esCromatografia de líquidsNitrosaminesTermodinàmicaLiquid chromatographyNitrosoaminesThermodynamicsinfo:eu-repo/semantics/article6815292019-01-28info:eu-repo/semantics/openAccess30150116