Montanya Mias, Eduard2016-02-162016-02-162014-03-150012-1797https://hdl.handle.net/2445/69464The global epidemic of type 2 diabetes is largely secondary to insulin resistance induced by obesity and sedentary lifestyles. Most insulin-resistant subjects are able to increase b-cell secretion to meet the increased insulin demand and do not develop diabetes. However, when b-cell compensation fails, type 2 diabetes develops (1,2). Understanding the mechanisms of this compensatory response is of fundamental importance to elucidate the pathophysiology of type 2 diabetes and has implications for the treatment of the disease.3 p.application/pdfengcc-by-nc-nd (c) American Diabetes Association, 2014http://creativecommons.org/licenses/by-nc-nd/3.0/esResistència a la insulinaIllots de LangerhansInsulin resistanceIslands of Langerhansinfo:eu-repo/semantics/article6568092016-02-16info:eu-repo/semantics/openAccess