Quintairos Domenech, LuisColom Codina, HelenaMillán, OlgaFortuna, VirginiaEspinosa, CristinaGuirado, LluísBudde, KlemensSommerer, ClaudiaLizana, AnaLópez Púa, YolandaBrunet i Serra, Mercè2021-03-232021-03-232021-01-221932-6203https://hdl.handle.net/2445/175587Previous results from our group and others have shown that urinary pellet expression of miR155-5p and urinary CXCL-10 production could play a key role in the prognosis and diagnosis of acute rejection (AR) in kidney transplantation patients. Here, a logistic regression model was developed using NONMEM to quantify the relationships of miR155-5p urinary expression, CXCL-10 urinary concentration and tacrolimus and mycophenolic acid (MPA) exposure with the probability of AR in adult kidney transplant patients during the early post-transplant period. Owing to the contribution of therapeutic drug monitoring to achieving target exposure, neither tacrolimus nor MPA cumulative exposure was identified as a predictor of AR in the studied population. Even though CXCL-10 urinary concentration showed a trend, its effect on AR was not significant. In contrast, urinary miR155-5p expression was prognostic of clinical outcome. Monitoring miR155-5p urinary pellet expression together with immunosuppressive drug exposure could be very useful during routine clinical practice to identify patients with a potential high risk of rejection at the early stages of the post-transplant period. This early risk assessment would allow for the optimization of treatment and improved prevention of AR.20 p.application/pdfengcc-by (c) Quintairos, Lluís et al., 2021http://creativecommons.org/licenses/by/3.0/esMarcadors bioquímicsFarmacocinèticaTrasplantament renalFactors de risc en les malaltiesBiochemical markersPharmacokineticsKidney transplantationRisk factors in diseasesinfo:eu-repo/semantics/article7073942021-03-23info:eu-repo/semantics/openAccess33481955