Incoronato, MariarosariaUrso, LoredanaPortela, AnnaLaukkanen, Mikko O.Soini, YlermiQuintavalle, YlermiKeller, SimonaEsteller, Manel, 1968-Condorelli, Gerolama2018-11-302018-11-302011-11-15https://hdl.handle.net/2445/126610Many studies have shown that microRNA expression in cancer may be regulated by epigenetic events. Recently, we found that in lung cancer miR-212 was strongly down-regulated. However, mechanisms involved in the regulation of miR-212 expression are unknown. Therefore, we addressed this point by investigating the molecular mechanisms of miR-212 silencing in lung cancer. We identified histone modifications rather than DNA hypermethylation as epigenetic events that regulate miR-212 levels in NSCLC. Moreover, we found that miR-212 silencing in vivo is closely associated with the severity of the disease.10 p.application/pdfengcc by (c) Incoronato et al., 2011http://creativecommons.org/licenses/by/3.0/es/ADNCàncer de pulmóDNALung cancerinfo:eu-repo/semantics/article7002562018-07-24info:eu-repo/semantics/openAccess22110741