Amat Tusón, MercedesPinto, AlexandreGriera Farres, RosaBosch Cartes, Joan2017-03-072017-03-072015-07-210947-6539https://hdl.handle.net/2445/108026The marine alkaloids (-)-lepadins A-C and (+)-lepadin D, belonging to two diastereoisomeric series, were synthesized from an (R)-phenylglycinol-derived tricyclic lactam via a common cis-decahydroquinoline intermediate. Crucial aspects of the synthesis are the stereochemical control in the assembly of the cis-decahydroquinoline platform, in the introduction of the C2 methyl and C3 hydroxy substituents, and in the generation of the C5 stereocenter.5 p.application/pdfeng(c) Wiley-VCH, 2015AlcaloidesLactamesCompostos heterocíclicsSíntesi asimètricaAlkaloidsLactamsHeterocyclic compoundsAsymmetric synthesisinfo:eu-repo/semantics/article6555882017-03-07info:eu-repo/semantics/openAccess26202059