Bosch Hereu, LluísCialîcu, IonelaCaner, JoaquimAriza Piquer, XavierCosta i Arnau, Anna M.Terrazas Martínez, MontserratVilarrasa i Llorens, Jaume2014-04-032014-04-032012-03-140040-4039https://hdl.handle.net/2445/53208Pd-catalysed reactions of 2-Cl, 2-Br and 2-I derivatives of a 6-chloropurine nucleoside with benzamide have been compared, using Pd2dba3, Xantphos and Cs2CO3 in toluene, between 20 and 80 °C. The reactivity order was 2-I > 2-Br > 6-Cl ≫ 2-Cl. The 2-I substituent could be replaced even at 0 °C, under conditions disclosed here for the first time. On the other hand, the replacement of the chlorine atom at position 2 (2-Cl) required 110 °C.5 p.application/pdfeng(c) Elsevier Ltd, 2012Àcids nucleicsCompostos heterocíclicsCitotoxicitat per mediació cel·lularNucleòsidsMedicaments antineoplàsticsNucleic acidsHeterocyclic compoundsCell-mediated cytotoxicityNucleosidesAntineoplastic agentsinfo:eu-repo/semantics/article6057862014-04-03info:eu-repo/semantics/openAccess