Grijalvo, SantiagoTerrazas Martínez, MontserratAviñó Andrés, AnnaEritja i Casadellà, Ramon2021-09-022021-09-022010-04-010960-894Xhttps://hdl.handle.net/2445/179826Two different series of oligonucleotide-peptide conjugates have been efficiently synthesized by stepwise solid-phase synthesis. First, oligonucleotides and oligonucleotide phosphorothioates containing polar groups at the 3′-termini, such as amine and guanidinium groups were prepared. ODNs conjugates carrying several lysine residues were obtained directly from Fmoc deprotection whereas ODN conjugates with guanidinium groups were obtained by post-synthetic guanidinylation. The second family contains different urea moieties that were achieved by standard protocols. All products were fully characterized by reversed phase HPLC and MALDI-TOF mass spectrometry yielding satisfactory results. Oligonucleotide-phosphorothioate conjugates were evaluated as potential antisense oligonucleotides in the inhibition of the luciferase gene.4 p.application/pdfeng(c) Elsevier Ltd, 2010OligonucleòtidsUreaPèptidsOligonucleotidesUreaPeptidesinfo:eu-repo/semantics/article7134352021-09-02info:eu-repo/semantics/openAccess