Dierssen Sotos, TrinidadPalazuelos-Calderón, CamiloJiménez Moleón, José JuanAragonès Sanz, NúriaAltzibar, Jone M.Castaño-Vinyals, GemmaMartín Sánchez, VicenteGómez Acebo, InésGuevara, MarcelaTardón, AdoninaPérez Gómez, BeatrizAmiano, PilarMoreno Aguado, VíctorMolina de la Torre, Antonio JoséAlonso Molero, JéssicaMoreno Iribas, ConchiKogevinas, ManolisPollán, MarinaLlorca Díaz, Javier2019-07-152019-07-152018-03-121471-2407https://hdl.handle.net/2445/137201BACKGROUND: Reproductive factors are well known risk factors for breast cancer; however, little is known about how genetic variants in hormonal pathways interact with that relationship. METHODS: One thousand one hundred thirty nine cases of breast cancer in women and 1322 frequency-matched controls were compared. Genetic variants in hormonal pathways (identified in the Kyoto Encyclopedia of Genes and Genomes) were screened according to their relationship with breast cancer using the Cochran-Armitage statistic. Information on reproductive factors was obtained using a face-to-face questionnaire. The interaction among the selected genetic variants and reproductive factors was tested with logistic regression. RESULTS: Concerning C allele in rs2229712, compared to nulliparity in non-carriers the ORs for 1-2 and > 2 deliveries were 0.48 (0.28-0.81) and 0.34 (0.19-0.59), and in C carriers they were 0.92 (0.42-1.98) and 0.71 (0.31-1.61). Similar results were found in women carrying the C allele in rs1269851. Carriers of Allele T in rs35652107 and allele C in rs6018027 had the delivery number effect more pronounced. CONCLUSIONS: The number of deliveries had a dose-response protective effect on breast cancer; women carrying C allele in rs2229712 did not benefit from this protective effect.9 p.application/pdfengcc-by (c) Dierssen Sotos, Trinidad et al., 2018http://creativecommons.org/licenses/by/3.0/esCàncer de mamaReproducció humanaGenèticaBreast cancerHuman reproductionGeneticsinfo:eu-repo/semantics/article6853082019-07-15info:eu-repo/semantics/openAccess29530003