García Pindado, JúliaRoyo, SoledadTeixidó Turà, MeritxellGiralt Lledó, Ernest2017-05-082018-03-162017-03-161075-2617https://hdl.handle.net/2445/110580Several natural peptides have a biaryl or biaryl ether motif in their biologically active structures. A model bicyclic pentapeptide containing a biaryl bridge has been synthesized by solid-phase peptide synthesis combining on-resin Suzuki and Miyaura cross-coupling reactions. Its biological properties in terms of permeability, stability and cytotoxicity have been studied, demon-strating the positive contribution of the biaryl bridge, excellent membrane penetration and serum stability9 p.application/pdfeng(c) European Peptide Society and John Wiley & Sons, 2017Síntesi de pèptidsProductes naturalsSíntesi orgànicaPeptide synthesisNatural productsOrganic synthesisinfo:eu-repo/semantics/article2017-05-08info:eu-repo/semantics/openAccess