Vila Farrés, XavierParra Millán, RaquelSánchez Encinales, VivianaVarese, MonicaAyerbe Algaba, RafaelBayó Puxan, NúriaGuardiola Bagán, SalvadorPachón Ibáñez, María EugeniaKotev, MartinGarcía Arroyo, JesúsTeixidó Turà, MeritxellVila Estapé, JordiPachón, JerónimoGiralt Lledó, ErnestSmani, Younes2018-05-162018-05-162017-10-312045-2322https://hdl.handle.net/2445/122399Preventing the adhesion of pathogens to host cells provides an innovative approach to tackling multidrug-resistant bacteria. In this regard, the identification of outer membrane protein A (OmpA) as a key bacterial virulence factor has been a major breakthrough. The use of virtual screening helped us to identify a cyclic hexapeptide AOA-2 that inhibits the adhesion of Acinetobacter baumannii, Pseudomonas aeruginosa and Escherichia coli to host cells and the formation of biofilm, thereby preventing the development of infection in vitro and in a murine sepsis peritoneal model. Inhibition of OmpA offers a strategy as monotherapy to address the urgent need for treatments for infections caused by Gram-negative bacilli.11 p.application/pdfengcc-by (c) Vila Farres, Xavier et al., 2017http://creativecommons.org/licenses/by/3.0/esBacteris gramnegatiusMalalties bacterianesGram-negative bacteriaBacterial diseasesinfo:eu-repo/semantics/article6741132018-05-16info:eu-repo/semantics/openAccess29089624