Pujol, NúriaPenadés Rubio, RafaelJunqué i Plaja, Carme, 1955-Dinov, IvoFu, Cynthia H. Y.Catalán Campos, RosaIbarretxe Bilbao, NaroaBargalló Alabart, NúriaBernardo Arroyo, MiquelToga, ArthurHoward, Robert J.Costafreda, Sergi G.2026-01-302026-01-302014-09-110007-1250https://hdl.handle.net/2445/226480Background: Hippocampal abnormalities have been demonstrated in schizophrenia. It is unclear whether these abnormalities worsen with age, and whether they affect cognition and function. Aims: To determine whether hippocampal abnormalities in chronic schizophrenia are associated with age, cognition and socio-occupational function. Method: Using 3 T magnetic resonance imaging we scanned 100 persons aged 19-82 years: 51 were out-patients with stable schizophrenia at least 2 years after diagnosis and 49 were healthy volunteers matched for age and gender. Automated analysis was used to determine hippocampal volume and shape. Results: There were differential effects of age in the schizophrenia and control samples on total hippocampal volume (group × age interaction: F(1,95) = 6.57, P = 0.012), with steeper age-related reduction in the schizophrenia group. Three-dimensional shape analysis located the age-related deformations predominantly in the mid-body of the hippocampus. In the schizophrenia group similar patterns of morphometric abnormalities were correlated with impaired cognition and poorer socio-occupational function. Conclusions: Hippocampal abnormalities are associated with age in people with chronic schizophrenia, with a steeper decline than in healthy individuals. These abnormalities are associated with cognitive and functional deficits, suggesting that hippocampal morphometry may be a biomarker for cognitive decline in older patients with schizophrenia.19 p.application/pdfeng(c) The Royal College of Psychiatrists, 2014Hipocamp (Cervell)EsquizofrèniaHippocampus (Brain)Schizophreniainfo:eu-repo/semantics/article6441572026-01-30info:eu-repo/semantics/openAccess25213158